Generic Name: glipizide (GLIP i zide)
Brand Names: GlipiZIDE XL, Glucotrol, Glucotrol XL
What is Glucotrol XL (glipizide)?
Why managing blood sugar is so important.
Glipizide is an oral diabetes medicine that helps control blood sugar levels. This medication helps your pancreas produce insulin.
Glipizide is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes.
Glipizide may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Glucotrol XL (glipizide)?Do not use this medication if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.
Before taking glipizide, tell your doctor if you have kidney or liver disease, chronic diarrhea or a blockage in your intestines, glucose-6-phosphate dehydrogenase deficiency (G6PD), a disorder of your pituitary or adrenal glands, a history of heart disease, or if you are malnourished.
Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.
Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your glipizide dose.
Glipizide is only part of a complete program of treatment that may also include diet, exercise, weight control, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.
What should I discuss with my doctor before taking Glucotrol XL (glipizide)?Do not use this medication if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.
To make sure you can safely take glipizide, tell your doctor if you have any of these other conditions:
- liver disease;
- kidney disease;
chronic diarrhea or a blockage in your intestines;
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
a disorder of your pituitary or adrenal glands;
a history of heart disease; or
if you are malnourished.
How should I take Glucotrol XL (glipizide)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Take glipizide 30 minutes before a meal. If you take glipizide once daily, take it 30 minutes before breakfast.
Glipizide extended-release (Glucotrol XL) should be taken with breakfast.Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating.
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Your doctor may want you to stop taking glipizide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.Ask your doctor how to adjust your glipizide dose if needed. Do not change your medication dose or schedule without your doctor's advice.
Some forms of glipizide are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect and will not make the medication less effective.
Glipizide is only part of a complete program of treatment that may also include diet, exercise, weight control, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose 30 minutes before your next meal, then return to your regular schedule. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Use glipizide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
What happens if I overdose?Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.A glipizide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid while taking Glucotrol XL (glipizide)?Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Glucotrol XL (glipizide) side effectsGet emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking glipizide and call your doctor at once if you have a serious side effect such as:
easy bruising or bleeding (nosebleeds, bleeding gums), feeling tired or short of breath, rapid heart rate;
pale or yellowed skin, dark colored urine, fever, confusion; or
throbbing headache, severe nausea and vomiting, fast or pounding heartbeats, sweating or thirst, feeling like you might pass out.
Less serious side effects may include:
nausea, stomach pain;
dizziness, drowsiness; or
skin rash, redness, or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Glucotrol XL Side Effects
Generic Name: glipizide,glipizide xl,glucotrol
Please note - some side effects for Glucotrol XL may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
Side Effects of Glucotrol XL - for the Consumer
Glucotrol XL Extended-Release Tablets
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Glucotrol XL Extended-Release Tablets:
Seek medical attention right away if any of these SEVERE side effects occur when using Glucotrol XL Extended-Release Tablets:
Diarrhea; dizziness; gas; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; skin redness; dizziness); confusion; dark urine; fainting; fever, chills, or persistent sore throat; irregular heartbeat; low blood sugar symptoms (eg, anxiety, drowsiness, fast heartbeat, headache, lightheadedness, severe or persistent dizziness, tremors, unusual sweating, weakness); severe or persistent blurred vision or other vision problems; unusual bruising or bleeding; unusual tiredness or weakness; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.Top
Glucotrol XL Side Effects - for the Professional
Glucotrol XLRead More...
What other drugs will affect Glucotrol XL (glipizide)?
You may be more likely to have hyperglycemia (high blood sugar) if you are taking glipizide with other drugs that raise blood sugar, such as:
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others);
niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
diet pills, medicines to treat asthma, colds or allergies; and
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others.
You may be more likely to have hypoglycemia (low blood sugar) if you are taking glipizide with other drugs that lower blood sugar, such as:
- nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim and others);
a monoamine oxidase inhibitor (MAOI);
beta-blockers (Tenormin and others);
a blood thinner (warfarin, Coumadin and others); and
other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), or rosiglitazone (Avandia).
These lists are not complete and there are many other medicines that can increase or decrease the effects of glipizide on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Glucotrol XL resources
- Glucotrol XL Advanced Consumer (Micromedex) - Includes Dosage Information
- Glucotrol XL Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
- Glucotrol XL Prescribing Information (FDA)
- Glipizide Prescribing Information (FDA)
- Glipizide Professional Patient Advice (Wolters Kluwer)
- Glipizide Monograph (AHFS DI)
- Glipizide MedFacts Consumer Leaflet (Wolters Kluwer)
- Glipizide XL Prescribing Information (FDA)
- Glucotrol Consumer Overview
- Glucotrol Prescribing Information (FDA)
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